5-Amino-1MQ
A small-molecule NNMT inhibitor (not a peptide) studied in cell and animal research; no human trials and no approval anywhere.
What it is
5-Amino-1MQ is not a peptide at all — it's a small-molecule inhibitor of NNMT, an enzyme that influences cellular energy balance. It appears in this library because peptide-market catalogs sell it alongside everything else, usually as a 'fat loss' capsule or injection.
Its entire evidence base is cell and rodent research, where NNMT inhibition increased fat-cell energy expenditure and reduced diet-induced obesity in mice. No human study of any kind has been published.
What researchers have actually studied it for
Fat-cell metabolism and diet-induced obesity — in mice and cell culture only.
How it works
It blocks nicotinamide N-methyltransferase (NNMT), an enzyme abundant in fat tissue that consumes methyl groups and influences NAD+-adjacent metabolism. Inhibit NNMT in a mouse and its fat cells burn more energy — an elegant finding awaiting any human confirmation.
Where it came from
NNMT emerged as an obesity target from academic metabolism research in the 2010s, with 5-amino-1-methylquinolinium appearing in a series of rodent papers as the tool inhibitor. It jumped from lab-reagent catalogs to wellness marketing with unusual speed and zero clinical development in between.
What the research record actually contains
- Rodent studies: reduced fat mass and improved metabolic markers with NNMT inhibition.
- Cell-culture work on fat-cell energy metabolism.
- No published human research — none.
What's known about risks
Completely uncharacterized in humans. NNMT sits at a busy metabolic intersection (methylation and NAD+ pathways), which makes 'no human data' a heavier caveat than usual.
Where it stands legally
No approval anywhere; sold through research-chemical and supplement-gray channels.
Worth asking a licensed provider
- 1.Am I clear this is a lab compound with zero human studies?
- 2.If fat loss is the goal, why not the approved options with actual trial evidence?
- 3.What in my labs would even suggest a metabolic-enzyme experiment makes sense?