Side-by-Side Comparison
Compare up to 4 peptides by what they are, their regulatory status, and the level of human evidence. This page does not rank peptides by effectiveness.
Comparison FAQ
What's the difference between semaglutide and tirzepatide?
Semaglutide activates the GLP-1 receptor; tirzepatide activates GLP-1 and GIP together. In head-to-head trial data tirzepatide showed greater average weight reduction, but individual response, tolerability, availability and price all differ — averages don't pick your prescription, a prescriber does.
Can I compare an approved drug with a research peptide?
Side by side on this tool, yes — and that's the point: the comparison makes the evidence gap visible. An approved drug brings controlled trials; a research compound brings animal studies. They can share a table, not an evidence tier.
What's the difference between retatrutide and tirzepatide?
Tirzepatide is an approved dual agonist (GLP-1/GIP). Retatrutide adds a third target (glucagon receptor) and is still investigational — in trials, not approved, with its safety profile still being established. Products sold online under its name sit outside that process entirely.
How should I use this comparison tool?
As a way to structure questions, not answers: compare regulatory status first, evidence level second, and bring the gaps you find to a licensed provider. The tool deliberately won't tell you what to take.